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Gastrointestinal Carcinoid Tumor Cure - Gastrointestinal Carcinoid
Tumor Medicine Drug
Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. Carcinoid tumors are discrete, yellow, well-circumscribed tumors that can occur anywhere along the gastrointestinal tract (GI). They most commonly affect the appendix, ileum, and rectum. These tumors are unique in that they are endocrine in nature. They secrete hormones into the blood stream, which then travel to end organs and act upon them via appropriate receptors. Although quite rare, 15 cases/1,000,000 population, carcinoid tumors account for 75% of GI endocrine tumors.
Contents [hide] 1 Clinical presentation 2 Pathophysiology 3 Diagnosis 4 Localization of tumour 5 Treatment 6 Prognosis 7 Synonyms 8 References 9 See also 10 External links
[edit] Clinical presentation Clinical findings include:[1]
Flushing of the skin Diarrhea and abdominal cramps Right sided heart disease - fibrosis of the tricuspid valve bronchoconstriction abdominal pain due to desmoplastic reaction of the mesentery in most patients, increased urinary excretion of 5-HIAA (5-hydroxyindoleacetic acid), a degradation product of serotonin Serotonin causes fibrosis of the tricuspid and pulmonary valves "TIPS" - Tricuspid Insufficiency, Pulmonic Stenosis (fibrosis of tricuspid and pulmonary valves) This short section requires expansion.
[edit] Pathophysiology Carcinoid tumors produce the vasoactive substance, serotonin; it is commonly but incorrectly thought that serotonin is the cause of the flushing. The flushing results from secretion of kallikrein, the enzyme that catalyzes the conversion of kininogen to lysyl-bradykinin. The latter is further converted to bradykinin, one of the most powerful vasodilators known. Other components of the carcinoid syndrome are diarrhea (probably caused by serotonin), a pellagra-like syndrome (probably caused by diversion of large amounts of tryptophan from synthesis of the vitamin, niacin, to the synthesis of 5-hydroxyindoles including serotonin), fibrotic lesions of the endocardium, particularly on the right side of the heart resulting in insufficiency of the tricuspid valve and, less frequently, the pulmonary valve and, uncommonly, bronchoconstriction. The pathogenesis of the cardiac lesions and the bronchoconstriction is unknown. When the primary tumor is in the gastrointestinal tract, as it is in the great majority of cases, the serotonin and kallikrein are inactivated in the liver; manifestations of carcinoid syndrome do not occur until there are metastases to the liver. Carcinoid tumors arising in the bronchi may be associated with manifestations of carcinoid syndrome without liver metastases because their biologically active products reach the systemic circulation before passing through the liver and being metabolized.
[edit] Diagnosis With a certain degree of clinical suspicion, diagnosis is made primarily by measuring plasma levels of the secreted glycoprotein Chromogranin A, supported by measuring the 24 hour urine levels of 5-HIAA (5-hydroxyindoleacetic acid), a breakdown product of serotonin. Patients with carcinoid syndrome usually excrete >25 mg of 5-HIAA per day. For localization of both primary lesions and metastasis, the initial imaging method is Octreoscan, where 111Indium labelled somatostatin analogues (octreotide) are used in scintigraphy for detecting tumors expressing somatostatin receptors. Median detection rates with octreoscan are about 89%, in contrast to other imaging techniques such as CT scan and MRI with detection rates of about 80%. Usually on CT scan, one will note a spider-like/crab like change in the mesentery due to the fibrosis from the release of serotonin. PET scans, which evaluate for increased metabolism of glucose, may also aid in localizing the carcinoid lesion or evaluating for metastases.
[edit] Localization of tumour Tumour localization may be extremely difficult. Barium swallow and follow-up examination of the intestine may occasionally show the tumour. Capsule video endoscopy has recently been used to localize the tumour. Often laparotomy is the definitive way to localize the tumour.
[edit] Treatment For symptomatic relief of carcinoid sydrome:
Octreotide (somatostatin analogue- neutralizes serotonin and decreases urinary 5-HIAA) Methysergide maleate (antiserotonin agent but not used because of serious side effect of retroperitoneal fibrosis) Cyproheptadine (antihistamine) Alternative treatment for qualifying candidates:
Surgical resection of tumor and chemotherapy (5-FU and doxorubicin)
[edit] Prognosis Prognosis varies from individual to individual. It ranges from a 95% 5 year survival for localized disease to a 20% 5 year survival for those with liver metastases. The average survival time from the start of octreotide treatment has increased to about 12 years.
[edit] Synonyms Thorson-Bioerck syndrome, argentaffinoma syndrome, Cassidy-Scholte sydrome, flush syndrome
[edit] References ^ E.Goljan, Pathology, 2nd ed Mosby Elsevier, Rapid Review series. "Endocrine Tumors of the GI Tract and Pancreas." Harrison's Manual of Medicine. Eugene Braunwald. 15th edition. New York: McGraw-Hill, 2002. 298-299. "Malignant Carcinoid Syndrome." Current Medical Diagnosis & Treatment. Lawrence M. Tierney, Jr. 43rd edition. New York: Lange Medical Books/McGraw-Hill, 2004. 1625. "Carcinoid Syndrome." Griffith's 5 Minute Clinical Consult. Mark Dambro. Mobile Version 6.0.139. Lippincott, Williams and Wilkins, 2003. "Current Status of Gastrointestinal Carcinoids." Gastroenterology. Irvin M. Modlin et al. 2005;128;1717-1751.
[edit] See also Kulchitsky cells
[edit] External links Caring for Carcinoid Foundation Merck http://www.netumoradvisor.org http://www.carcinoid.org
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